Calcium/Calmodulin-Dependent Kinase II Mediates the Phosphorylation and Activation of NADPH Oxidase 5
نویسندگان
چکیده
منابع مشابه
Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5.
Excessive synthesis of reactive oxygen species contributes to the pathology of many human diseases and originates from changes in the expression and posttranslational regulation of the transmembrane NADPH oxidases (Noxes). Nox5 is a novel Nox isoform whose activity is regulated by intracellular calcium levels. We have reported that the activity and calcium-sensitivity of Nox5 can also be modula...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2011
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.110.070193